The role of acetylcholinesterase (AChE) in neurotransmission is well known. But long before synapses are formed in vertebrates, AChE is expressed in young postmitotic neuroblasts that are about to extend the first long tracts. AChE histochemistry can thus be used to map primary steps of brain differentiation. Preceding an possibly inducing AChE in avian brains, the closely related butyrylcholinesterase (BChE) spatially fore-shadows AChE-positive cell areas and the course of their axons. In particular, before spinal motor axons grow, their corresponding rostral (...) sclerotomes and myotomes express BChE, and both their neuronal source and myotomal target cells express AChE. Since axon growth has been found inhibited by acetylcholine, it is postulated that both cholinetsreases can attract neurite growth cones by neutralizing the inhibitor. Thus, the early expression of both cholinesterases that is at least partially independent from classical cholinergic synaptogenesis, sheds new light on the developmental and medical significance of these enzymes. (shrink)

This paper introduces a new, expanded range of relevant cognitive psychological research on collaborative recall and social memory to the philosophical debate on extended and distributed cognition. We start by examining the case for extended cognition based on the complementarity of inner and outer resources, by which neural, bodily, social, and environmental resources with disparate but complementary properties are integrated into hybrid cognitive systems, transforming or augmenting the nature of remembering or decision-making. Adams and Aizawa, noting this distinctive complementarity argument, (...) say that they agree with it completely: but they describe it as “a non-revolutionary approach” which leaves “the cognitive psychology of memory as the study of processes that take place, essentially without exception, within nervous systems.” In response, we carve out, on distinct conceptual and empirical grounds, a rich middle ground between internalist forms of cognitivism and radical anti-cognitivism. Drawing both on extended cognition literature and on Sterelny’s account of the “scaffolded mind” (this issue), we develop a multidimensional framework for understanding varying relations between agents and external resources, both technological and social. On this basis we argue that, independent of any more “revolutionary” metaphysical claims about the partial constitution of cognitive processes by external resources, a thesis of scaffolded or distributed cognition can substantially influence or transform explanatory practice in cognitive science. Critics also cite various empirical results as evidence against the idea that remembering can extend beyond skull and skin. We respond with a more principled, representative survey of the scientific psychology of memory, focussing in particular on robust recent empirical traditions for the study of collaborative recall and transactive social memory. We describe our own empirical research on socially distributed remembering, aimed at identifying conditions for mnemonic emergence in collaborative groups. Philosophical debates about extended, embedded, and distributed cognition can thus make richer, mutually beneficial contact with independently motivated research programs in the cognitive psychology of memory. (shrink)

A book review of Raffaella De Rosa's Descartes and the Puzzle of Sensory Representation".

Ongoing and anticipated COVID-19 human challenge studies in the UK may advance our understanding of COVID-19 and facilitate the licensure of safe, effective, and easily deployable next-generation COVID-19 vaccines and boosters. We argue that international volunteer recruitment for COVID-19 human challenge trials can help promote diversity in these trials and ensure a sufficient number of eligible volunteers, both of which will increase the benefits of challenge research. We explore the ethical ramifications of dealing with unfair background conditions of global vaccine (...) injustice to expand medical research, and conclude that international recruitment for COVID-19 human challenge trials can be conducted ethically provided that several robust protections are in place for volunteers. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

Medicine is often thought of as a science of the body, but it is also a science of data. In some contexts, it can even be asserted that data drive health. This article focuses on a key piece of data technology central to contemporary practices of medicine: the medical record. By situating the medical record in the perspective of its history, we inquire into how the kinds of data that are kept at sites of clinical encounter often depend on informational (...) requirements that originate well outside of the clinic, in particular in health insurance records systems. Although this dependency of today's electronic medical records on billing requirements is widely lamented by clinical providers, its history remains little studied. Following the archaeology of medicine developed by Michel Foucault in The Birth of the Clinic and expanding his methodology in light of more recent contributions to the field of media archaeology, this article excavates some of the underexplored technological conditions that help constitute today's electronic medical record. If in some contexts, it is true that data drive health, then an archaeology of medical records helps reveal how health insurance records often impact clinical care and, by extension, health and disease. (shrink)

According to anti-atomism, we represent color properties (e.g., red) in virtue of representing color relations (e.g., redder than). I motivate anti-atomism with a puzzle involving a series of pairwise indistinguishable chips. I then develop two versions of anti-atomism.

In this paper we briefly examine and evaluate Quine’s physicalism. On the supposition, in accordance with Quine’s views, that there can be no change of any sort without a physical change, we argue that this point leaves plenty of room to understand and accept a limited autonomy of the special sciences and of other domains of disciplinary and common-sense inquiry and discourse. The argument depends on distinguishing specific, detailed programs of reduction from the general Quinean strategy of reduction by explication. (...) We argue that the details of the relations of particular sciences, disciplines and domains of discourse depend on empirical evidence and empirical-theoretical developments and that the generalized approach of reduction by explication is also subject to related empirical-theoretical constraints. So understood, physicalism lacks much of the controversial force and many of the implications sometimes associated with it. (shrink)

Examples of extended cognition typically involve the use of technologically low-grade bio-external resources (e.g., the use of pen and paper to solve long multiplication problems). The present paper describes a putative case of extended cognizing based around a technologically advanced mixed reality device, namely, the Microsoft HoloLens. The case is evaluated from the standpoint of a mechanistic perspective. In particular, it is suggested that a combination of organismic (e.g., the human individual) and extra-organismic (e.g., the HoloLens) resources form part of (...) a common mechanism that realizes a bona fide cognitive routine. In addition to demonstrating how the theoretical resources of neo-mechanical philosophy might be used to evaluate extended cognitive systems, the present paper illustrates one of the ways in which mixed reality devices, virtual objects (i.e., holograms), and online (Internet-accessible) computational routines might be incorporated into human cognitive processes. This, it is suggested, speaks to the recent interest in mixed/virtual reality technologies across a number of disciplines. It also introduces us to issues that cross-cut disparate fields of philosophical research, such as the philosophy of science and the philosophy of technology. (shrink)

In Paul Moser’s view, philosophical arguments of natural theology are irrelevant as evidence for God’s existence. I argue that embracing Moser’s view would bring about the end to the project and practice of Christian apologetics as we know it. I draw out implications from Moser’s work on religious epistemology for the project of Christian apologetics. I sketch what Christian apologetics would look like if one were to embrace Moser’s call to eliminate arguments as evidence for God existence. The result (...) of embracing Moser-style apologetics is apologetics without argument. I argue that Moserian apologetics should be rejected. (shrink)

Ang Noli Me Tangere at El Filibusterismo ay mga nobelang isinulat ni Dr. Jose P. Rizal na sumasalamin sa kalagayan ng mga Pilipino noong panahon ng mga Español. Ikinubli ni Rizal ang mga di-makatáong pagtrato ng mga Español sa mga itinuring na Indio sa pamamagitan ng mga pangyayari at mga karakter sa kaniyang dalawang akda. Mula sa Teorya ng Moral na Pag-unlad (Theory of Moral Development) ng isang Amerikanong Sikolohistang si Lawrence Kohlberg ay sinuri ng papel na ito ang 10 (...) tagpo na nagpapakita ng katungkulang moral sa dalawang nobela gámit ang Antas at Yugto ng Moral na Pag-unlad ni Kohlberg (Kohlberg’s Levels and Stages of Moral Development). Mula sa ginawang pagsusuri, napagtanto ng papel na ito na gumamit si Rizal ng estratehiya upang ipakita na ang aksiyong isinagawa ng ahente sa bawat tagpo ay taliwas sa kaniyang kabuoang moralidad, bagaman ang pamamaraang ito ay nagdulot sa mga mambabása ng Noli Me Tangere at El Filibusterismo ng iba’t ibang interpretasyon at pagkaunawa sa mga isinulat ng may-akda. Mapanghámon ang mga nobela ni Rizal na sumusubok sa tradisyonal na kaugalian at panuntunan ng Pilipinas maging sa pagkukunwari ng lipunang Pilipino. Malaki ang naging gampanin ng nabuong tema na sumisimbolo sa mga isyung panlipunang nais palutangin ni Rizal. Gayunpaman, dahil sa mataas na pangangatwirang moral na nakapaloob sa kaniyang mga gawa, nararapat na gamítin ito hindi lámang bílang materyal sa pagaaral ng Filipino at sa mga kaugnay na larang, kundi pati rin sa pag-aaral ng kritisismo sa politika at lipunan, maging sa pag-aaral ng etika at moralidad, partikular na sa konteksto ng Pilipinas. (shrink)

The market failures approach to business ethics has recently garnered substantial critical attention (see, e.g., Cohen and Peterson 2019; Moriarty 2020; Steinberg 2017; Hsieh 2017; von Kriegstein 2016; Smith 2018; Endorfer and Larue 2022; Singer 2018). Though precursors of this view can be found in the literature (e.g., McMahon 1981; Friedman 1970), it was Joseph Heath (2004, 2006, 2014, 2023) who developed the approach and gave it its name. The market failures approach (henceforth: MFA) is concerned with the ethical obligations (...) of managers of firms (Heath 2014, 69). Roughly, it holds that managers ought not to conduct their businesses in a way that exploits market failures. “Market failure” is a technical term, meaning any failure of the conditions of the first fundamental welfare theorem, sometimes called the “Pareto conditions” (see Arrow 1951). The theorem states that if the Pareto conditions hold, then the market equilibrium will use society’s scarce resources efficiently, meaning that no one could be made better-off without making anyone else worse off. Efficiency, according to Heath (2014, chapter 7), is the implicit morality of the market. We coordinate much of our shared activity using markets, Heath claims, because of their ability to produce efficient results. Markets are good forms of social organization, according to Heath, because they are the best way to promote our values given empirical facts about the frailties of human psychology and the informational constraints that we face. As such, managers ought not compromise the very conditions that justify a market economy by profiting from breakdowns in the market’s efficiency. Managers are permitted to maximize profits, so long as they do not violate the market’s norm of efficiency in so doing. This is because the fundamental justification for the profit motive is that it is necessary for the operation of the price system which is essential to the efficiency properties of markets. In this paper, I will argue that the MFA is more general than even Heath himself claims. The MFA describes the professional obligations of managers, but the view I develop, the generalized market failures approach, describes the obligations of all market participants. Since efficiency is the implicit morality of the market, it binds not just managers, but all market participants, including consumers, investors and workers. Market participants are permitted to maximize the benefit they gain from market interactions, as long as they do so in a way that does not take advantage of any market failures. Generalizing the MFA in this way has three benefits: first, we gain a unified understanding of the ethics of non-managerial market roles; second, we will develop an even better understanding of the duties of managers; finally, it gives us the resources to respond to some familiar objections to the MFA found in the literature. In the next section, I will further motivate the MFA and explain how this motivation can be easily generalized to other market roles. Importantly, one can avoid benefiting from a market failure in two distinct ways: by avoiding transactions that exploit market failures or by transacting in such markets and then remediating the harm done, by compensating those negatively affected by the market failure. This section concludes by discussing how the remediation duties are to be split between the transacting parties and how to identify the parties to whom compensation is owed. In section 3, I use the tools of the generalized MFA to develop a unified ethics of consumption, investment and labor, respectively. This is the basis of a grand abductive argument for the generalized MFA. The view is strongly supported by the fact that it provides attractive and unifying explanations of our obligations in domains as variegated as carbon offsetting, CEO compensation, the reparations white Americans owe to black Americans and occupational licensure. Section 4 briefly concludes. (shrink)

Although our concepts of “Mama,” “milk,” and “mice” have much in common, the suggestion that they are identical in structure in the mind of the prelinguistic child is mistaken. Even infants think about objects as different from substances and appreciate the distinction between kinds (e.g., mice) and individuals (e.g., Mama). Such cognitive capacities exist in other animals as well, and have important adaptive consequences.

English translation of an article originally published in French in Liber Amicorum Pascal Engel, J. Dutant, G. Fassio & A. Meylan (eds.), University of Geneva, 2014, pp. 581-608. In what follows, I strive to present the elements of a philosophical doctrine, which can be defined as dialectical contextualism. I proceed first to define the elements of this doctrine: dualities and polar contraries, the principle of dialectical indifference and the one-sidedness bias. I emphasize then the special importance of this doctrine in (...) one specific field of meta-philosophy: the methodology for solving philosophical paradoxes. Finally, I describe several applications of this methodology on the following paradoxes: Hempel's paradox, the surprise examination paradox and the Doomsday Argument. (shrink)

Although the word 'sustainability' is used broadly, scientific approaches to sustainability fall into one of two competing paradigms. Following the influential Brundtland report of 1987. some theorists identify sustainability with some form of resource availability, and develop indicators for sustainability that stress capital depletion. This approach has spawned debates about the intersubstitutivity of capitals, with many environmental theorists arguing that at some point, depletion of natural capital cannot be offset by increases in human or social capital. The alternative approach is (...) grounded in stock and flow systems systems modeling, and defines sustainability through indicators that determine whether the system structure is robust (e.g. resists perturbation), resilient (recovers after disruption) and adaptive (capable of change in response to external conditions). Both paradigms have applications in economics and ecology. (shrink)

Paul Silva has recently argued that doxastic justification does not have a basing requirement. An important part of his argument depends on the assumption that doxastic and moral permissibility have a parallel structure. I here reply to Silva's argument by challenging this assumption. I claim that moral permissibility is an agential notion, while doxastic permissibility is not. I then briefly explore the nature of these notions and briefly consider their implications for praise and blame.

.... The strategy I have defended involves drawing a distinction between those who can and cannot legitimately hold an agent responsible in circumstances when the agent is being covertly controlled (e.g. through implantation processes). What is intuitively unacceptable, I maintain, is that an agent should be held responsible or subject to reactive attitudes that come from another agent who is covertly controlling or manipulating him. This places some limits on who is entitled to take up the participant stance in relation (...) to agents who are rational self-controllers but nevertheless subject to covert control.26 In this way, what is compromised by conditions of covert control is not the responsibility of the agent as such. It is, rather, the participant stance of those other agents who covertly control him. Clearly it is possible to establish these specific limits on who can hold these agents responsible without denying that the agents themselves remain free and responsible. When we take this approach we will find that we are no longer faced with an unattractive choice between simply “biting the bullet” or having to “spit it out”. All we need to do is chew carefully, until there is nothing left that we find too hard to swallow. (shrink)

In this paper, I look at Susan Stebbing’s articles and reviews that critically engage logical positivism. These appeared before the publication of A.J. Ayer’s Language, Truth and Logic and helped shape the early British reception of logical positivism. I highlight Stebbing’s adoption of G.E. Moore’s tripartite distinction between knowing a proposition, understanding it, and giving an analysis of it and, in light of this distinction, her focus on whether the principle of verifiability can ground a plausible account of communication. Stebbing (...) thinks not, and I reconstruct her reasons, as well as her own account of communication. In doing this, I relate her criticisms to her rejection of methodological solipsism and her dissatisfaction with the logical positivist treatment of statements about other minds and the past. I also argue that Stebbing’s work provides a bridge to later criticisms of logical positivism from ordinary language philosophers. Foregrounding Stebbing’s engagement with logical positivism, especially her focus on communication, paints a fuller picture of how the logical positivists came to be part of analytic philosophy despite having different concerns than many of the British philosophers engaging their work. (shrink)

Appears to give the first model-theoretic account of both "must" and "ought" (without conflating them with one another). Some key pre-theoretic semantic and pragmatic phenomena that support a negative answer to the main title question are identified and a conclusion of some significance is drawn: a pervasive bipartisan presupposition of twentieth century ethical theory and deontic logic is false. Next, an intuitive model-theoretic framework for "must" and "ought" is hypothesized. It is then shown how this hypothesis helps to explain and (...) predict all the pre-theoretic phenomena previously observed. Next, I show that the framework hypothesized possesses additional expressive and explanatory power (e.g. derivatively predicting the existence of supererogatory and permissibly suboptimal alternatives), thus adding further confirmation that it is on the right track. (shrink)

G.E.M. Anscombe famously remarked that an adequate philosophy of psychology was needed before we could do ethics. Fifty years have passed, and we should now ask what significance our best theories of the psychology of agency have for moral philosophy. My focus is on non-moral conceptions of autonomy and self-governance that emphasize the limits of deliberation -- the way in which one's cares render certain options unthinkable, one's intentions and policies filter out what is inconsistent with them, and one's resolutions (...) function to block further reflection. I argue that we can expect this deliberative "silencing" to lead to moral failures that occur because the morally correct option was filtered out of the agent's deliberation. I think it follows from these conceptions of self-governance that we should be considered culpable for unwitting acts and omissions, even if they express no ill will, moral indifference, or blameworthy evaluative judgments. The question is whether this consequence is acceptable. Either way, the potential tradeoff between self-governance and moral attentiveness is a source of doubt about recent attempts to ground the normativity of rationality in our concern for self-governance. (shrink)

Grice bu yazıda temel olarak sezdirim kavramını incelemektedir. Sezdirim bir karşılıklı konuşmada konuşucunun, söylediği şey ötesinde dinleyicisine aktardığı düşüncedir. Konuşma sezdirimleri söz konusu olduğunda dinleyici, bir çıkarım sonucunda sezdirimleri saptar. Grice'ın savı, bu çıkarımda nicelik, nitelik, bağıntı ve tarz olmak üzere dört grupta toplanabilen ilkelerin (maksimler) belirleyici rol oynadığıdır.

Don Ihde has characterized his philosophy as "phenomenology + pragmatism." This article argues that Ihde's pragmatism can be understood as consistency with two philosophical commitments from the first generation of American pragmatists (e.g. Peirce, James, Dewey and Addams). First, Ihde's notion of embodiment relations for tools and techniques is consistent with the organism-environment relational epistemology of these thinkers. Second, his desire to dissociate himself from romantic and neo-idealist readings of the phenomenological tradition link him with their naturalism.

RÉSUMÉL'interprétation de la philosophie pratique de Donald Davidson proposée par Robert Myers représente correctement maints aspects fondamentaux de sa pensée. Myers soutient à juste titre que Davidson évite les incohérences entre la position internaliste, l'objectivité éthique et le modèle croyance-désir en modifiant des éléments centraux de ce modèle, et que l'alternative proposée par Davidson rend légitime l'extension des arguments de l'interprétation et de la triangulation dans la sphère pratique. Cependant, Myers s’égare à une bifurcation cruciale de la route interprétative. Davidson (...) suit G.E.M. Anscombe sur une voie différente, une voie qui considère les désirs individuels comme constitués en partie par des jugements évaluatifs. (shrink)

Four initial postulates are presented (with two more added later), which state that construction of the physical universe proceeds from a sequence of discrete steps or "projections" --- a process that yields a sequence of discrete levels (labeled 0, 1, 2, 3, 4). At or above level 2 the model yields a (3+1)-dimensional structure, which is interpreted as ordinary space and time. As a result, time does not exist below level 2 of the system, and thus the quantum of action, (...) h, which depends on time (since its unit is time•energy), also does not exist below level 2. This implies that the quantum of action is not fundamental, and thus e.g. that the physical universe cannot have originated from a quantum fluctuation. When the gravitational interaction for the model is developed, it is seen that the basic ingredient for gravity is already operating at level 1 of the system, which implies that gravity, too, is not fundamentally quantum mechanical (since, as stated, h only kicks in at level 2) --- perhaps obviating the need for a quantum theory of gravity. Further arguments along this line lead to the conclusion that quantum fluctuations cannot be a source of gravity, and thus cannot contribute to the cosmological constant --- thereby averting the cosmological constant problem. Along the way, the model also provides explanations for dark energy, the beginning and ending of inflation, quark confinement, and more. Although the model dethrones the quantum, it nevertheless elevates an idea in physics that was engendered by quantum mechanics: the necessary role of "observers" in constructing the world. (shrink)

The Mach-Zehnder Interferometer (MZI) is chosen to illustrate the long-standing wave-particle duality problem. Why is which-way (welcher weg) information incompatible with wave interference? How do we explain Wheeler’s delayed choice experiment? Most crucially, how can the photon divide at the first beam splitter and yet terminate on either arm with its undiminished energy? The position advanced is that the photon has two identities, one supporting particle features and the other wave features. There is photon kinetic energy that never splits (on (...) half-silvered mirrors) or diffracts (in pinholes or slits). Then there are photon probability waves that do diffract and can reinforce or cancel. Photon kinetic energy is oscillatory; its cycles require/occupy time. E = mc2 suggests that kinetic energy is physically real as occurrence in time just as rest mass is physically real as existence in space; both are quantized and both occupy/require a dimension for their occurrence or existence. Photon kinetic energy (KE) thus resides in time, but is still present/available for interactions (events) in space; rest mass (e.g., your desk) resides in space but is still present/available for interactions (events) in time. While photon probability waves progress in space and diffract there, photon KE resides in time and never diffracts in space; at reception it always arrives whole and imitates particle impact without being a particle. Photon probability waves are real; they diffract in space. Acknowledging that the photon has two identities (residing energy and progressing probability), explains photon dual nature. And wave-particle duality is central to quantum mechanics. Understanding it leads to new insights into entanglement, nonlocality and the measurement problem. A 30-minute video on nonlocality and photon dualism can be found by a google: search “youtube klevgard nonlocality”). (shrink)

with some reference to my graffiti and arrest at U of G.

A história da psicologia, tal como aparece em algumas obras (E.G. Boring 1950; M. Reuchlin 1957; P. Fraisse e J. Piaget 1963) ou em capítulos introdutórios de alguns manuais (M. Reuchlin 1977), reflete uma adesão — raramente discutida — a uma concepção internalista. Segundo essa concepção, a psicologia seria animada por uma dinâmica própria, um processo evolutivo totalmente endógeno, e seria independente de fatores externos tais como os domínios religiosos, sociopolíticos e econômicos. Além do mais, os partidários dessa história aceitam (...) ver a psicologia influenciada por disciplinas situadas em suas fronteiras, como a biologia, a fisiologia e, em menor medida, a física. Esses domínios fronteiriços geralmente dizem respeito a objetos psicológicos habitualmente qualificados de inferiores, como reflexos, sensações e percepções, em oposição à linguagem e ao pensamento, qualificados como processos superiores. Esses mesmos domínios fronteiriços engendraram por sua vez subdomínios relativamente autônomos, tais como a psicofísica ou a psicofisiologia. Correlativamente a essa concepção internalista, o desenvolvimento científico é apresentado como um caminho ao estado de psicologia positiva, tal como A. Comte a definiu em 1837 na 45a lição do Curso de Filosofia Positiva. A caminhada até a positividade foi indicada pelo próprio A. Comte: estudo da anátomo-fisiologia do sistema nervoso (a frenologia de Gall lhe parece a esse respeito uma contribuição decisiva), estudos comparados, análise de casos patológicos, estudo dos comportamentos animais e do desenvolvimento individual. Considerando a evolução da psicologia nos últimos cem anos, seríamos tentados a sustentar que ela realizou o projeto positivista. Psicologia diferencial, psicopatologia, etologia animal e psicologia da criança são vários domínios que concorrem para essa realização. Entretanto, esses domínios estão longe de parecerem homogêneos quanto aos métodos empregados e os modelos epistemológicos aos quais se referem. Um exame atento dessas dimensões metodológicas e epistemológicas mostra que se avança, sobretudo, em ordem dispersa. (shrink)

My review of Boghossian's book, Fear of Knowledge, is generally sympathetic toward his rejection of epistemic relativism and turns toward an examination of "constructivist" themes in light of an anti-nominalist perspective. In general terms, this is a fine little book, tightly argued, and well worth considerable attention--especially from the friends of relativism and those supporting versions of constructivism. (Constructivism + radical nominalism = relativism.).

Most of us intuitively take discrimination based on gender or ethnicity to be impermissible because we have a right to be treated on the basis of merit and capacity rather than e.g. ethnicity or gender. I call this suggestion the Impermissibility Account. I argue that, despite how the Impermissibility Account seems intuitive to most of us with a humanist outlook, it is indefensible. I show that well-informed discrimination can sometimes be permissible, and even morally required, meaning we cannot have a (...) strict right not to be discriminated against. I then propose an alternative and more plausible account which I call the Fairness and Externalities Account, arguing that acts of discrimination are wrong partly because they are unfair and partly because they create harmful externalities which—analogously to pollution—there is a collective responsibility to minimize. Both of these factors are however defeasible, meaning that if the Fairness and Externalities Account is correct, then discrimination is sometimes permissible. These results are counterintuitive, and suggest that the ethics of discrimination requires further attention. (shrink)

Molecular developmental biology has expanded our conceptions of gene actions, underpinning that embryonic development is not only governed by a set of specific genes, but as much by space–time conditions of its developing modules. Typically, formation of cellular spheres, their transformation into planar epithelia, followed by tube formations and laminations are modular steps leading to the development of nervous tissues. Thereby, actions of organising centres, morphogenetic movements, inductive events between epithelia, tissue polarity reversal, widening of epithelia, and all these occurring (...) orderly in space and time, are driving forces of emergent laminar neural tissues, e.g. the vertebrate retina. Analyses of self-organisational formation of retina-like 3D structures from dispersed cells under defined cell culture conditions demonstrate that not only particular genetic networks, but—at least as important—the applied culture conditions define phenotypes of emergent tissues. Such in vitro approaches allow assigning emerging tissue formation to ground-laying genetic networks separately from contributions by conditional constraints. (shrink)

This paper proposes an interpretation of time that is an 'A-theory' in that it incorporates both McTaggart's A-series and his B-series. The A-series characteristics are supposed to be 'ontologically private' analogous to qualia in the problem of other minds and is given a definition. The main idea is that the experimenter and the cat do not share the same A-series characteristics, e.g the same 'now'. So there is no single time at which the cat gets ascribed different states. It is (...) proposed one may define a 'unit of becoming' that coordinatizes the future/present/past 'private' spectrum as well as allowing one to calculate the rates of becoming. Relativity is briefly considered. (shrink)

In the introduction I argue that the basic element (or primitive) for constructing the physical universe is "displacement from a prior level", and the basic structure is "a sequence of such displacements" (summarized as postulates 1 and 2). The displacements are then defined as one-dimensional objects with a direction (postulate 3). The relations between these displacements are stated in postulate 4. In section 2 we discuss basic consequences of the postulates, and in section 3 we use the postulates to derive (...) a (3+1)-dimensional structure, interpreted as ordinary space and time. We then derive further properties of space --- isotropy, homogeneity, and a rapid early expansion (i.e. inflation). Time, comporting with experience, is shown to be a one-dimensional stream --- with a direction. In section 4 we associate energy with the displacements, and find that the same factors that construct ordinary space (and make it isotropic and homogeneous) also smear the locations of entities/particles across that space --- thereby providing a mechanism/explanation for that iconic and enigmatic aspect of quantum mechanics. We also determine that there must be a continual, uniformly-distributed stream of (non-zero-point) energy coming into the system that constructs new space (i.e. dark energy). The streaming natures of both time and dark energy are shown to have the same basic cause: the processes that input dark energy into the system, and that construct time, are themselves independent of time --- and so they are continual processes. Further consequences follow from the model, including an explanation for why the presence of energy affects space and time, and why quantum vacuum energy is an exception to this rule (i.e. does not gravitate) --- thereby eliminating the cosmological constant problem. A key benefit of the model is that it liberates us from always having to think about the construction of the universe in terms of spatio-temporal relations and evolution (e.g. the big bang model), which is problematic because presumably (and as we will indeed see) space and time are products of the fundamental construction process, not things that govern it. (shrink)

This paper proposes an interpretation of time that is an 'A-theory' in that it incorporates both McTaggart's A-series and his B-series. The A-series characteristics are supposed to be 'ontologically private' analogous to qualia in the problem of other minds, such as in the Inverted Spectrum thought experiment, and is given a definition. The main idea is then that the experimenter and the cat do not share the same A-series characteristics, e.g. the same 'now', to some extent. So there is no (...) single time at which the cat gets ascribed different states, one by the experimenter and one by the cat. Also it is proposed one may define an ontologically private 'unit of becoming' that coordinatizes the future/present/past A-series spectrum as well as allow one to calculate rates of becoming with seconds. The latter are taken to measure differences in B-series times. (shrink)

Der endliche Mensch hat Probleme bei W a h r n e h m u n g oder V o r s t e l l u n g eines „unendlichen“ Raumes: als gleichzeitig oder als nacheinander. Die Vorstellung eines solchen Raumes führt für Paul Sturm zu einem Widerspruch. Dabei will er nicht stehen bleiben. Die Vorstellung dieses Raumes möchte er durch das D e n k e n „erweitern und vervollständigen“. Darin sieht er die Lösung dieses Konfliktes. Er (...) möchte das Bewusstsein dafür schärfen, dass sich das „Unendliche“ nicht vorstellen, sondern nur denken lässt. In der richtigen Formulierung der Problemstellung sieht Sturm ihre Lösung. Er legt dar, dass eine falsche Methode in der Vergangenheit stets zu einem Widerspruch führte, der sich als Sophisma (irrtümliche Schlussfolgerung) erweist. (Zusammenfassung verfasst von Michael Sturm-Berger und Beate Sturm). (shrink)

The article traces the evolution and crystallization of Buber’s philosophy of dialogue. It focuses on his consideration of the epistemological and ontological issues attendant to the principium individuationis, the subject of his doctoral dissertation of 1904. Culminating with the publication of Ich und Du in 1923, this process was punctuated by life experiences that led him to affirm rather than to seek to transcend the principium individuationis as the ontological ground of being manifest in the matrix of everyday life, which (...) we are beckoned to sanctify through I-Thou relations. (shrink)

Never was dogmatic reductionism helpful in conceiving the phenomenon of life. The post-genomic era has made it clear that genes alone cannot explain the functioning of whole organisms. Already each cell represents a unique, non-recurring individual. Recent progress in developmental biology has conveyed new perspectives both on the makings of individual organisms (ontogeny), as on evolutionary change (Evo-Devo). The genome (the entirety of all genes) of an animal remains constant from fertilization onwards in each cell. The realization of genes requires (...) molecular environments, in particular pertinent to the cytoplasm of the unfertilized egg. Individuality of an organism therefore is not only determined by its genome, but is shaped through developmental processes (it needs time!). Organisms can only exist through mutual interplays with their respective (molecular and cellular) environments at all levels of organization. Thus, life can be conceived of as endless networks of communication, e.g. as a mutual continuum, connecting all individuals, all species and all generations within their given environments. Evolutionarily, nature does not select fitting genes, but rather viable traits. The presented concepts render it unlikely that it was genes that founded our living world, but rather that distinct environments shaped “genes” (of whatever chemical nature) which proved to be “life-suitable”. (shrink)

Cambridge’deki büyük akademik cemaatin sakinleri olan bizler bir araya geldik ve hoşgörü ve onun egemen politik iklim içerisindeki yeri hakkında dostça ama ateşli bir tartışma yürüttük. Okuyucu, bizim nerelerde aynı düşüncede olmadığımızı bulmakta hiçbir zorluk çekmeyecektir. Diğer taraftan, farklı başlangıç noktalarından ve farklı yollardan hareketle yaklaşık olarak aynı yere ulaştık. Her birimiz için, egemen hoşgörü kuramı ve pratiğinin, incelendiği takdirde, korkunç politik gerçekleri gizlemeye yarayan bir maske olduğu ortaya çıktı. Kızgınlığın tonu makaleden makaleye keskin bir şekilde artmakta; belki de boş (...) yere, okuyucuların bu noktaya getiren akıl yürütmeyi takip edeceklerini umuyoruz. Nihayetinde bu kızgınlık hem kafa hem de kalpte ikamet etmektedir…. (shrink)

In this paper, I explore a tension between the Law in the novel The Island of Doctor Moreau, by H. G. Wells, and Kant's reciprocity thesis. The Law is a series of prohibitions that Moreau has his beasts recite. Moreau devotes his time to transforming animals through a painful surgery into beings that resemble humans, but the humanized beasts are constantly slipping back into animalistic habits, and so Moreau promulgates the Law to maintain decorum. Kant's reciprocity thesis states that free (...) will is the necessary and sufficient condition of moral practical laws. That is, in order for a moral practical law to be applicable, there must be free will, and, if free will is present, then there will be a moral practical law that sets a standard for the free will. However, in Wells's novel, the humanized beasts seem to lack free will. So, how can a law be applicable to them? By delving deeper into the mystery of Moreau's strange island, I will shed light on the otherwise cumbersome concepts of free will, natural impulses, and practical laws, as well as their interrelationships. The upshot will be a deeper understanding of personhood through an exploration of the instinctual nature of animals, moral law, and free will. (shrink)

John Schellenberg has advanced the hiddenness argument against God’s existence, based on the idea that an all-loving God would seek personal relationships. This paper develops a reply to Schellenberg’s argument by examining the notion of moral impurity, as understood by Paul the Apostle. Paul conceptualized moral impurity as a causal state that transfers from person to person, like a contagious disease. He also believed that moral impurity precludes divine-human relationship. The goal of this paper is to develop these (...) ideas into a problem for one Schellenberg’s key premises. (shrink)

We review some of the main implications of the free-energy principle (FEP) for the study of the self-organization of living systems – and how the FEP can help us to understand (and model) biotic self-organization across the many temporal and spatial scales over which life exists. In order to maintain its integrity as a bounded system, any biological system - from single cells to complex organisms and societies - has to limit the disorder or dispersion (i.e., the long-run entropy) of (...) its constituent states. We review how this can be achieved by living systems that minimize their variational free energy. Variational free energy is an information theoretic construct, originally introduced into theoretical neuroscience and biology to explain perception, action, and learning. It has since been extended to explain the evolution, development, form, and function of entire organisms, providing a principled model of biotic self-organization and autopoiesis. It has provided insights into biological systems across spatiotemporal scales, ranging from microscales (e.g., sub- and multicellular dynamics), to intermediate scales (e.g., groups of interacting animals and culture), through to macroscale phenomena (the evolution of entire species). A crucial corollary of the FEP is that an organism just is (i.e., embodies or entails) an implicit model of its environment. As such, organisms come to embody causal relationships of their ecological niche, which, in turn, is influenced by their resulting behaviors. Crucially, free-energy minimization can be shown to be equivalent to the maximization of Bayesian model evidence. This allows us to cast natural selection in terms of Bayesian model selection, providing a robust theoretical account of how organisms come to match or accommodate the spatiotemporal complexity of their surrounding niche. In line with the theme of this volume; namely, biological complexity and self-organization, this chapter will examine a variational approach to self-organization across multiple dynamical scales. (shrink)

We present a game mechanic called pseudo-visibility for games inhabited by non-player characters (NPCs) driven by reinforcement learning (RL). NPCs are incentivized to pretend they cannot see pseudo-visible players: the training environment simulates an NPC to determine how the NPC would act if the pseudo-visible player were invisible, and penalizes the NPC for acting differently. NPCs are thereby trained to selectively ignore pseudo-visible players, except when they judge that the reaction penalty is an acceptable tradeoff (e.g., a guard might accept (...) the penalty in order to protect a treasure because losing the treasure would hurt even more). We describe an RL agent transformation which allows RL agents that would not otherwise do so to perform some limited self-reflection to learn the training environments in question. (shrink)

The enigma of the Emergence of Natural Languages, coupled or not with the closely related problem of their Evolution is perceived today as one of the most important scientific problems. The purpose of the present study is actually to outline such a solution to our problem which is epistemologically consonant with the Big Bang solution of the problem of the Emergence of the Universe}. Such an outline, however, becomes articulable, understandable, and workable only in a drastically extended epistemic and scientific (...) oecumene, where known and habitual approaches to the problem, both theoretical and experimental, become distant, isolated, even if to some degree still hospitable conceptual and methodological islands. The guiding light of our inquiry will be Eugene Paul Wigner's metaphor of ``the unreasonable effectiveness of mathematics in natural sciences'', i.e., the steadily evolving before our eyes, since at least XVIIth century, ``the miracle of the appropriateness of the language of mathematics for the formulation of the laws of physics''. Kurt Goedel's incompleteness and undecidability theory will be our guardian discerner against logical fallacies of otherwise apparently plausible explanations. John Bell's ``unspeakableness'' and the commonplace counterintuitive character of quantum phenomena will be our encouragers. And the radical novelty of the introduced here and adapted to our purposes Big Bang epistemological paradigm will be an appropriate, even if probably shocking response to our equally shocking discovery in the oldest among well preserved linguistic fossils of perfect mathematical structures outdoing the best artifactual Assemblers. (shrink)

Paul Goodman, 1960’larda modern Amerikan toplumunun organize sistemi içerisinde dönemin gençliğinin sorunlarını ön plana çıkaran ‘Growing Up Absurd: Problems of Youth in the Organized System’ (Saçmayı Büyütmek: Organize Sistemde Gençliğin Problemleri, 1960) eseri ile sosyal bir eleştirmen olarak ön plana çıkmıştır. Amerikalı bir düşünür olan Paul Goodman’ın kısa öyküler, romanlar, şiirler ve makalelerden oluşan çalışmaları, siyaset, sosyal teori, eğitim, kentsel tasarım, edebi eleştiri, hatta psikoterapi gibi geniş bir yelpazeye dağılmıştır. Onun temel argümanı (1960: 9-10) tek bir merkez etrafında (...) örgütlenen teknoloji toplumunun başarısızlıklarını eleştirerek, mevcut düzenin insanın doğasına uygun bir biçimde yeniden inşasını vurgulamaktadır. Goodman’ın yeniden inşa süreci içerisinde insan doğasına önem veren faaliyete dayalı anarşist ideolojisi, sorumluluk duygusunun homojen bir şekilde bireyler arasında paylaşılması gerektiğini vurgular. Goodman merkeziyetçi olmayan siyaset anlayışı ile kendisini Amerikan siyasetinin ve kültürünün karşısında yer alan bir pozisyonda konumlandırmaktadır (Honeywell, 2011: 1). Diğer bir deyişle Goodman (1960: 36), anarşist geleneği formüle etmek amacıyla yirminci yüzyıl Amerikası’nın içinde bulunmuş olduğu mevcut durumdan yola çıkarak eleştirilerini ademi merkeziyetçilik, katılımcı demokrasi, özerk toplum temaları üzerine temellendirmiştir. -/- Goodman’a göre, sosyal, kültürel, ahlâk ve eğitim gibi alanlarda uygulanan kurallar günümüz devletlerini etkisi altına alan kapitalist düzen tarafından belirlenmektedir (Bakır, 2016: 110). Bu durum Goodman’ın da içerisinde bulunduğu anarşist düşünürler tarafından kabul edilebilecek bir husus değildir, çünkü anarşistler mevcut düzenin ve sosyal yaşamın otorite ve itaat yapılarıyla güçlendirilen belirli yaklaşımlar ile kontrol altına alınmasını, insanların fikirlerini özgürce ifade edemeyeceği, bir nevi entelektüel bir hapishane içerisinde yaşaması anlamına geleceğinden dolayı karşı çıkmaktadırlar (Sheean, 2003: 122). Aynı nedenlerden dolayı Goodman, modern liberalizm ve Marksizm gibi alternatif radikal ideolojileri yerinden yönetim düşüncesi ve sosyal mühendislik konusundaki eğilimleri dolayısıyla reddetmektedir. Goodman için anarşizm, özgürlük ve toplumsal değişime yeterli düzeyde arka çıkabilecek tek ideolojik çerçeve olarak görülmektedir. Ona göre (2010: 143), “anarşizm ya da daha iyisi, anarko-pasifizm (toplumsal değişim hareketleri içerisinde örgütlü şiddete ve kurumlara karşı çıkan anarşist anlayış) günümüzün gelişmiş toplumlarının bürokrasilerini, karar verme konusunda aşırı merkezîleşmelerini ve sosyal mühendislik gibi problematik durumlarını ve tehlikelerini tutarlı bir şekilde öngörmüştür”. -/- Siyaset, sosyoloji ve felsefe gibi çeşitli alanlar içerisinde etkili olan anarşist kuramlar, radikal bir söylem olarak eğitimcileri ve araştırmacıları yeni öğretilere ve uygulamalara teşvik etme konusunda itici bir güç oluşturabilmektedirler. Anarşist yaklaşımlardan eğitim kuramı ve araştırmalara yönelik daha belirleyici bir rol alması beklenmektedir, ancak bu yaklaşımlar mevcut radikal akademik görüşü büyük ölçüde etkisi altına alan Marksizm’in eğitim alanında göstermiş olduğu aynı etkiyi gösterememiştir. Anarşist düşünceleri eğitim alanı içerisinde daha etkili ve görünür kılabilmek amacıyla Paul Goodman, Francisco Ferrer ve Alexander Neill’ın ileri sürmüş olduğu çeşitli düşünceler, girişimler ve uygulamalar ortaya çıkmıştır. Bu doğrultuda Goodman’ın anarşizme ilişkin düşünceleri ile bu çalışma sıkı bir anarşizm tahlili, eleştirisi ve felsefesinden öte anarşist anlayışın eğitimdeki uygulanabilirliğine yönelik bir soruşturma içerisine girmekte ve anarşist yaklaşımın mevcut eğitim sistemlerinden hangi yönleriyle farklılaştığını, sonucunda etkili bir eğitim anlayışı ortaya koyup koyamadığını tartışmaktadır. (shrink)

Resumen: Siguiendo el hilo conductor de la pregunta sobre cómo se nos puede conceder un acceso a la poesía de Paul Celan, el artículo discute dos enfoques diferentes: por un lado, el de la experiencia hermenéutica de Hans-Georg Gadamer; por otro, el de la experiencia diseminal de Jacques Derrida. La intención de la confrontación de las posiciones opuestas respecto a la poesía de Celan no es ni examinar los supuestos y preposiciones de ambas posiciones ni impugnar la legitimidad de (...) una de ellas desde el punto de vista de la otra, sino establecer y evocar el sentido de la disensión, la significación del discernimiento entre ellas y, así, abrir un campo de posibilidad para ambas, para una hermenéutica y para una deconstrucción hoy; y a través de ello también, y sobre todo, un lugar y un tiempo para el poema de Celan, la posibilidad de escucharlo y oírlo, de convertirse en destinatario de su voz inter-(a)pelativa. Palabras clave “Du liegst”; Lenguaje hermético; Comprensión; H.G. Gadamer; J. Derrida // The Secret of the Encounter. Paul Celan’s Poetry between Hermeneutics and DeconstructionAbstract Following the guiding line of the question how an access to Paul Celan’s po-etry can be granted to us, the article discusses two different approaches: on the one hand, the hermeneutic experience of Hans-Georg Gadamer; on the other hand, the disseminating experience of Jacques Derrida. The intention of the confrontation of the opposing positions regarding Celan’s poetry is nei-ther to examine the suppositions and prepositions of both positions nor to contest the legitimacy of either of them from the viewpoint of the other, but rather to establish and evoke the sense of the dissention, the signification of the discernment between them and, thus, open up the field of possibility for both, for a hermeneutics and for a deconstruction today, and through it also, above all, a place and a time for Celan’s poem, the possibility to listen to it and to hear it, to become the addressee of its inter-(a)pellative voice. Keywords “Du liegst”; Hermetic language; Understanding; H.G. Gadamer; J. Derrida. -/- Este artículo fue traducido al español por Facundo Bey. (shrink)